Antidepressants Linked With the Lower Mortality in Comorbid Diabetes and Depression


Prescribing the antidepressants to people suffering from comorbid diabetes and depression lowered mortality by the rate of 35%, according to a study published online in The Journal of Clinical Endocrinology & Metabolism. (Antidepressants Linked With the Lower Mortality)

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While the US Centers for Disease Control & Prevention warns that the patients with diabetes are 2 to 3 times more likely to have depression than other people without diabetes, up to three of the quarters of those with diabetes and depression go without treatment.

?The incidence of the major depressive disorder among the individuals with diabetes is significantly higher than the general population,? said study corresponding author Vincent Chin-Hung Chen, MD, Ph.D., a professor at Chiayi Chang Gung Memorial Hospital and Chang Gung University in Puzi, Taiwan. ?Diabetes and depression each independently contribute to increasing total mortality.

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Comorbidity of diabetes and depression

Antidepressants Linked With the Lower Mortality

The retrospective, the population-based study followed to 53,412 patients in Taiwan diagnosed with depression and diabetes between the year 2000 and the year 2013 to gauge how antidepressant use affects the death rates. Researchers and scientists found that antidepressant use in the patient population significantly reduced their mortality.

Hazard ratios for the specific antidepressant categories were around 0.63 for selective serotonin reuptake inhibitors, about 0.58 for serotonin-norepinephrine reuptake inhibitors, approximately 0.20 for norepinephrine-dopamine reuptake inhibitors, approximately 0.60 for mirtazapine, around 0.73 for tricyclic/tetracyclic antidepressants, and around 0.52 for trazodone.

Contrary to the effect of the other antidepressants, reversible inhibitors of monoamine oxidase A (RIMAs) were associated with an increase in the total mortality, found in the study. Researchers identified a hazard ratio of 1.48 for RIMAs.

They also concluded that most of the antidepressants, aside from RIMAs, are linked with the significantly reduced the risk of mortality in patients with depression and comorbid diabetes.

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This data provides the further rationale for the screening and treating of the depression in persons who have diabetes, Dr. Chen said.

Jolynn Tumolo

Note: Depression Cure does not provide any type of medical advice, diagnosis, or treatment.





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